Palifermin Compared to Supersaturated Calcium Phosphate Rinse in Prevention of Severe Oral Mucositis after Stem Cell Transplantation in Patients Receiving Radiotherapy-Based Myeloablative Conditioning

Purpose: Oral mucositis (OM) is a common, debilitating complication of conditioning regimens for hematopoietic stem cell transplantation (HSCT). Supersaturated calcium phosphate rinse (SCPR) and palifermin have shown efficacy in preventing severe OM. However, whether their differs unknown. We aimed to compare the SCPR HSCT patients receiving myeloablative conditioning. Methods: A comprehensive review our institutional database was performed identify who received myeloablative-conditioning therapy over 5 years. All radiotherapy-based either or within study period were included. Most Fludarabine, Busulfan, total body irradiation (FBT). Patients divided into two groups based on OM prophylactic agent received. The primary outcome prevalence (WHO Grade 3 4). secondary outcomes are all-grade WHO 4 These compared between groups. Results: identified 26 122 prophylaxis. World Health Organization (WHO) significantly lower group (57% vs. 100%, p = 0.01). In addition, had (22% 62%, 0.0006). overall not different (86% 100% arm, 0.15). Subgroup analyses demonstrated improved with palifermin, regardless age, sex, disease status, donor type, diagnosis. Conclusion: When SCPR, use associated reduced severity